Full-Length Publications:

1. Ouyang M.^*, Huang H.^*, Shaner N., Remacle AG., Shiryaev SA., Strongin AY., Tsien RY., Wang Y. (2010) Simultaneous Visualization of Pro-tumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy Transfer. Cancer Research, Accepted

2. Poh Y.C., Na S., Chowdhury F., Ouyang M., Wang Y., Wang N. (2009) Rapid Activation of Rac GTPase in Living Cells by Force Is Independent of Src. PLoS ONE, 4(11):e7886

3. Wang Y., Wang N. (2009) FRET and Mechanobiology. Integrative Biology, 1(10):565-73

4. Wang Y.^*, Flores L.^*, Lu S., Miao H., Li Y.-S., Chien S. (2009) Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-kB Pathway via Actin and Tyrosine Kinases. Cellular and Molecular Bioengineering, 2(3):341-350

5. Kim T., Wang Y. (2009) Single cell imaging of calcium dynamics in response to mechanical stimulation. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling, In Press

6. Lu S., Wang Y. (2009) Application of FRET Biosensors and Computational Analysis for Live Cell Imaging. Proc. of SPIE. 7191 (719108):1-12

7. Kim T., Xu J., Dong R., Lu S., Nuzzo R., Wang Y. (2009) Visualizing the Effect of Microenvironment on the Spatiotemporal RhoA and Src Activities in Live Cells by FRET. Small, 5(12):1453-9.

8. Na S., Chowdhury F., Tay B., Ouyang M., Gregor M., Wang Y., Wiche G., Wang N. (2009) Plectin contributes to mechanical properties of living cells. Am J Physiol Cell Physiol, 296(4):C868-77

9. Seong J., Lu, S., Ouyang M., Huang H., Zhang J., Frame MC., Wang Y. (2009) Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chemistry & Biology (Cell Press), 16(1):48-57, (Cover Article)

10. Kim T., Seong J., Ouyang M., Sun, J., Lu, S., Hong J., Wang, N., Wang Y. (2009) Mechanical rigidity regulates Ca²⁺ oscillation via RhoA signaling pathway in human mesenchymal stem cells. Journal of Cellular Physiology, 218(2):285-93

11. ^*Eichorst J., ^*Lu S., Xu J., Wang, Y. (2008) Differential RhoA Dynamics in Migratory and Stationary Cells Measured by FRET and Automated Image Analysis. PLoS ONE, 3(12):e4082

12. Ouyang M., Sun J., Chien S., Wang Y. (2008) Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors, Proc Natl Acad Sci USA. 105(38):14353-8

13. Wang, Y., Shyy Y.-J., Chien, S. (2008) Fluorescence Proteins, Live Cell Imaging, and Mechanobiology: Seeing is Believing, Annual Review of Biomedical Engineering, 10:1-38 (Top 10 downloads)

14. Lu S., Ouyang M., Seong J., Zhang J., Chien, S., Wang Y. (2008) The Spatiotemporal Pattern of Src Activation at Lipid Rafts Revealed by Diffusion-Corrected FRET Imaging. PLoS Computational Biology, 4(7): e1000127, (Featured Research by PLoS Computational Biology)

15. Na S., Collin O., Chowdery F., Tay B., Ouyang M., Wang Y., Wang N. (2008) Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci USA. 105 (18):6626-31

16. Ouyang M., Lu S., Li X.-Y., Xu J., Seong J., Giepmans B., Shyy Y.-J., Weiss SJ, Wang Y. (2008) Directional MT1-MMP Activity in Live Cells Visualized by a FRET Biosensor, Journal of Biological Chemistry. 283 (25):17740-8

17. Wang Y., Lu S. (2008) The Application of FRET Biosensors to Visualize Src Activation. Proc. of SPIE. 6868 (68680A):1-9

18. Wang Y., Shyy, J.-Y., and Chien, S., (2008) “Fluorescence Live-Cell Imaging: Principles and Applications in Mechanobiology”. Bioengineering in Cell and Tissue Research, pp. 65-84

19. Wang Y. and Chien, S., (2007) “Analysis of Integrin Signaling by Fluorescence Resonance Energy Transfer”. Methods in Enzymology, 426:177-201

20. Botvinick, EL and Wang Y., (2007) “Laser Tweezers in the Study of Mechanobiology in Live Cells”. Methods in Cell Biology, 82:497-523

21. Wang Y., Chang JM., Chen K.-D., Li S., Li J., Wu C., Chien S. (2007) Selective Adapter Recruitment and Differential Signaling Networks by VEGF vs. Shear Stress. Proc Natl Acad Sci USA. 104 (21): 8875-9

22. Larina IV., Wang Y., Chien S., Lane ME., and Dickinson ME. (2007) On the way to subcellular imaging of mechanotransduction in the developing vasculature. Proc. of SPIE. 6535 (653504):1-6

23. Hu YL., Haga JH., Miao H., Wang Y., Li YS., Chien S. (2006) Roles of microfilaments and microtubules in paxillin dynamics. Biochem Biophys Res Commun. 348(4):1463-71.

24. Wang Y., Jin G., Miao H., Li J., Usami S., Chien S. (2006) Integrins Regulate VE-cadherin and Catenins: Dependence of This Regulation on Src, but not on Ras. Proc Natl Acad Sci USA. 103(6):1774-79.

25. Wang Y., Botvinick E., Zhao Y., Berns M., Usami S., Tsien R.Y., Chien S. (2005) Visualization of Mechanical Activation of Src. Nature. 434:1040.

26. Miao H., Hu Y., Shiu Y.-T., Yuan S., Zhao Y., Kaunas R., Wang Y., Jin G., Usami S., and Chien S. (2005) Effects of Flow Patterns on the Localization and Expression of VE-Cadherin at Vascular Endothelial Cell Junctions: In-vivo and In-vitro Investigations. Journal of Vascular Research. 42:77.

27. Wang Y., Chang JM., Li Y.-C., Li Y.-S., Shyy J. Y.-J., and Chien S. (2004) Shear Stress and VEGF Activate IKK via Flk-1/Cbl/Akt Signaling Pathway. Am J Physiol Heart Circ Physiol. 286(2):H685-92.

28. Shiu Y.-T., Li S., Yuan S., Wang Y., Nguyen P., Chien S. (2003) Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun. 303(2):548-55

29. Wang Y., Miao H., Li S., Chen K.-D., Li Y.-S., Yuan S., Shyy J. Y.-J., and Chien S., (2002) Interplay between integrins and FLK-1 in shear stress- induced signaling. Am J Physiol Cell Physiol. 283: C1540-1548

30. Miao H., Yuan S., Wang Y., Tsygankov A., Chien S. (2002) Role of Cbl in Shear-Activation of PI 3-kinase and JNK in Endothelial Cells. Biochem Biophys Res Commun. 292(4):892-9

31. Li S., Butler P., Wang Y., Hu Y., Han D., Usami S., Guan J.-L., Chien S. (2002). The role of the dynamic of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci USA 99(6):3546-51

32. Wu W., Wang Y., Yan Z., Wen G. (1999). The Dynamic Coupling Model for the Whole Circulation in Human Body. Acta Scientiarum Naturalium, Universitatis Pekinensis 35(3): 328-339

33. Wu W., Wen G., Yan Z., Wang Y., Zhang, Z. (1999). The Dynamic Coupling of Right Ventricle and Pulmonary Arteries. Acta Scientiarum Naturalium, Universitatis Pekinensis 35(3): 317-327

34. Wang Y., Wu W., Wen G. (1999). The Influence of Aortic Valve on the Cardiovascular Coupling. Journal of Hydrodynamics 14(1).

35. Wang Y., Wu W., Wen G. (1998). The Influence of Cardiovascular Dynamic Coupling on the Blood Pulse Wave Propagation in Human Body. Applied Mathematics and Mechanics 19(7):601-614